99.6% Purity Pharmaceutical Raw Material Erlotinib Hydrochloride

Model: pharma raw powder
Place of Origin: Hubei,China (Mainland)
Brand Name: Erlotinib Hydrochloride
CAS No.: 183319-69-9
Purity: 99%
Erlotinib Hydrochloride color: almost white
Erlotinib Hydrochloride appearence: powder
Erlotinib Hydrochloride Alias: Erlotinib Hydrochloride, Erlotinib HCL, Tarceva
Erlotinib Hydrochloride MF: C22H24ClN3O4
Erlotinib Hydrochloride MOQ: 10grams
Erlotinib Hydrochloride Usage: Antineoplastic, Selective epidermal growth factor receptor
Erlotinib Hydrochloride payment methods: T/T, Westeron Union, Money Gram, Bitcoin
Erlotinib Hydrochloride lead time: within 24hour after payment confirmed
Erlotinib Hydrochloride Standard: EP
Erlotinib Hydrochloride Delivery time: 5-7 days

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Product Description

Payment & Shipping Terms Supply Capacity
Unit Price:1.0 USDProduction Capacity:5000kg per month
Trade Term:FOB,CIFPacking:disguised package
Payment Terms:BItcoin, T/T, WU, Money GramDelivery Date:within 24 hours after...
Min. Order:10 Gram
Means of Transport:Ocean, express, Air

99.6% Purity Pharmaceutical Raw Material Erlotinib Hydrochloride

Antineoplastic Pharma Raw Powder Erlotinib Hydrochloride


Erlotinib hydrochloride Basic info 


Product Name Erlotinib hydrochloride

CAS 183319-69-9

MF C22H24ClN3O4

MW 429.9

Chemical Properties Off-White Solid

Usage Selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor. Antineoplastic

Erlotinib HCl is an HER1/EGFR inhibitor with IC50 of 2 nM.

Erlotinib HCl (OSI-744) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Phase 3.


Erlotinib hydrochloride Description


Erlotinib hydrochloride (trade name Tarceva) is a drug used to treat non-small cell lung cancer (NSCLC), pancreatic cancer and several other types of cancer. It is a receptor tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor (EGFR).



Erlotinib hydrochloride Application


1. Erlotinib hydrochloride is a kind of small molecule epidermal growth factor receptor tyrosine kinase reversible inhibitor. It is mainly used for the second-line or third-line treatment of locally advanced or metastatic non-small cell lung cancer and for the treatment of pancreatic cancer.


1)Non-small cell lung cancer (NSCLC).It is used as first-line treatment for metastatic NSCLC in patients with tumors that have certain epidermal growth factor receptor (EGFR) mutations.It is used for locally advanced or metastatic NSCLC in patients who have already been treated with chemotherapy.


2)Pancreatic cancer. It is used with gemcitabine hydrochloride in patients whose disease cannot be removed by surgery or has metastasized.Erlotinib hydrochloride is also being studied in the treatment of other types of cancer.


2. HER-1/EGFR tyrosine kinase inhibitors.


3. Erlotinib has shown a survival benefit in the treatment of lung cancer in phase III trials. The SATURN (Sequential Tarceva in Unresectable NSCLC) study found that erlotinib added to chemotherapy improved overall survival by 19%, and improved progression-free survival (PFS) by 29%, when compared to chemotherapy alone.


Erlotinib hydrochloride Specification


ItemsSpecificationsResults
AppearanceAlmost white to pale yellow powderAlmost white powder
IdentificationH-NMR, MSComplies
Heavy Metals≤20ppmComplies
Impurity A 0.10%0.05%
Impurity B0.10%0.03%
Any other impurity 0.10%(RRT≈1.18):0.02% (RRT≈1.59) :0.02%
Total impurity  0.10%0.05%
Loss on Drying 1.00%0.06%
Residue on ignition≤0.1%0.05%
Dichloromethane≤600ppm120ppm
Ethyl acetate≤5000ppmND
N-heptane≤5000ppmND
Ethanol≤5000ppm78ppm
Formamide≤220ppmND
N,N-dimethylformamide≤880ppmND
Related Impurity by HPLCSingle impurity ≤0.1%0.05%
Purity (HPLC)99.00%99.70%
Benzyl chloride≤1000ppm100ppm
2,4-Dichlorobenzyl chloride≤1000ppmND
Assay(On Dry Basis)98.5-101%99.50%
ConculsionThe results can conform to the Standard


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