99.6% Purity Pharmaceutical Raw Material Erlotinib Hydrochloride
Antineoplastic Pharma Raw Powder Erlotinib Hydrochloride
Erlotinib hydrochloride Basic info
Product Name Erlotinib hydrochloride
Chemical Properties Off-White Solid
Usage Selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor. Antineoplastic
Erlotinib HCl is an HER1/EGFR inhibitor with IC50 of 2 nM.
Erlotinib HCl (OSI-744) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Phase 3.
Erlotinib hydrochloride Description
Erlotinib hydrochloride (trade name Tarceva) is a drug used to treat non-small cell lung cancer (NSCLC), pancreatic cancer and several other types of cancer. It is a receptor tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor (EGFR).
Erlotinib hydrochloride Application
1. Erlotinib hydrochloride is a kind of small molecule epidermal growth factor receptor tyrosine kinase reversible inhibitor. It is mainly used for the second-line or third-line treatment of locally advanced or metastatic non-small cell lung cancer and for the treatment of pancreatic cancer.
1)Non-small cell lung cancer (NSCLC).It is used as first-line treatment for metastatic NSCLC in patients with tumors that have certain epidermal growth factor receptor (EGFR) mutations.It is used for locally advanced or metastatic NSCLC in patients who have already been treated with chemotherapy.
2)Pancreatic cancer. It is used with gemcitabine hydrochloride in patients whose disease cannot be removed by surgery or has metastasized.Erlotinib hydrochloride is also being studied in the treatment of other types of cancer.
2. HER-1/EGFR tyrosine kinase inhibitors.
3. Erlotinib has shown a survival benefit in the treatment of lung cancer in phase III trials. The SATURN (Sequential Tarceva in Unresectable NSCLC) study found that erlotinib added to chemotherapy improved overall survival by 19%, and improved progression-free survival (PFS) by 29%, when compared to chemotherapy alone.
Erlotinib hydrochloride Specification
|Appearance||Almost white to pale yellow powder||Almost white powder|
|Impurity A ||0.10%||0.05%|
|Any other impurity ||0.10%||(RRT≈1.18):0.02% (RRT≈1.59) :0.02%|
|Total impurity ||0.10%||0.05%|
|Loss on Drying ||1.00%||0.06%|
|Residue on ignition||≤0.1%||0.05%|
|Related Impurity by HPLC||Single impurity ≤0.1%||0.05%|
|Assay(On Dry Basis)||98.5-101%||99.50%|
|Conculsion||The results can conform to the Standard|
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