Ketoprofen Anti-Inflammatory Pharmacuetical Raw Mateiral Ketoprofen
USP Standard Ketoprofen Anti-Inflammatory Raw Powder Ketoprofen
Ketoprofen Basic Info
EC No.: 244-759-8
Molecular Formula: C16H14O3
Molecular Weight: 254.28
Acidity or Alkalinity: PH3-4
Specific Rotation: +1°~ -1°
Melting Point: 92.0oC- 97.0oC
Residue on ignition: not more than 0.2%.
Appearance: white crystalline powder,Odourlessness
Solubility: practically insoluble in water, freely soluble in acetone, in alcohol and in methylene chloride.
Function and Use: It mainly used to treat rheumatoid arthritis, osteoarthritis and other rheumatic diseases.
Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain, and helps to relieve symptoms of arthritis (osteoarthritis and rheumatoid arthritis), such as inflammation, swelling, stiffness, and joint pain. This medicine does not cure arthritis and will help you only as long as you continue to take it .
Ketoprofen is generally prescribed for arthritis-related inflammatory pains or severe toothaches that result in the inflammation of the gums.
(1) ketoprofen,drinking and other non-steroidal anti-inflammatory drug used in conjunction, will increase the gastrointestinal side effects, but also cause the risk of ulcers.
(2) ketoprofen, aspirin or other salicylic acid drug with the same time, can not increase the efficacy of gastrointestinal side effects and increased incidence of bleeding tendency.
(3)ketoprofen, anticoagulant with the use of increased risk of bleeding.
(4) ketoprofen should not be used with methotrexate to prevent poisoning.
(5) ketoprofen, probenecid and verapamil, nifedipine with the use, pay attention to reduce the dose; with digoxin with the time, pay attention to adjust the digoxin dose.
Ketoprofen Uses for aryl alkyl acid compounds. With analgesic, anti-inflammatory and antipyretic effect. Anti-inflammatory effect than ibuprofen strong side effects, low toxicity. Oral easily absorbed from the gastrointestinal tract. After 1 dose, about o. 5 to 2 hours up to plasma peak concentration. And t 1/2 is 1.6 to 1.9 hours. In the blood and plasma protein binding strong. In the 24 hours from the urinary excretion rate of 30% to 90%. Mainly in the form of glucuronic acid excretion. For rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, joint hard spondylitis, and gout, etc.
|Appearance||White crystalline powder||White crystalline powder|
|Identification||Infrared Absorption/Ultraviolet Absorption|
Compares with Authentic Spectrum (KBr)
/Compares with Authentic Spectrum
|Loss on drying||≤0.5% ||0.14%|
|Residue on Ignition||≤0.2%||0.04%|
|Assay(By Titrimetry) on Dried Basis||98.5%~101.0%||99.26%|
|Conculsion||The results can conform to the USP37 Standard|
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