|Payment & Shipping Terms ||Supply Capacity |
|Unit Price:||160.0~290.0 USD||Production Capacity:||100000L/WEEK|
|Payment Terms:||T/T, WU, Money Gram, bitcoin||Packing:||brand new|
|Min. Order:||100 ml||Delivery Date:||with 6 working hours|
|Means of Transport:||Air|
Synonyms:TIANEPTINE;7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)-amino]heptanoic acid s,s-dioxide;7-[(3-CHLORO-6,11-DIHYDRO-6-METHYL-DIBENZO[C,F][1,2]THIAZEPINE-11-YL)AMINO]HEPTANOIC ACID S,S DIOXIDE;Tianeptineacid;COAXIL;7-[(3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-y1)amino]heptanoic acid S,S-dioxide;30123-17-2 (Mono-hydrochloride salt);Brn 1232295
Tianeptine is neuroprotective via multiple neurochemical and cellular mechanisms. In theory, tianeptine's neuroprotective action makes it a potential life-extension drug. When an organism is under stress, or perceives itself under stress, the hypothalamus secretes corticotropin-releasing hormone/factor (CRH/CRF). CRH/CRF in turn increases secretion of adrenocorticotrophic hormone (ACTH) from the anterior pituitary.
ACTH in turn stimulates the release of glucocorticoids from the adrenal cortex. Persistent, uncontrolled physical and psychosocial stress causes excess cortisol secretion from the adrenal glands. Excess cortisol causes dendritic shrinkage in the hippocampus and a contrasting growth of dendrites in the lateral amygdala. These stress-induced changes tend to lower mood; they can cause clinical depression in the genetically vulnerable.
Current evidence suggests that tianeptine acts to prevent and even reverse stress-induced neural damage, promoting both neuronal survival and synaptic plasticity.
Tianeptine has strong antidepressant and anxiolytic properties with a relative lack of sedative, anticholinergic and cardiovascular adverse effects, thus suggesting it is particularly suitable for use in elderly patients and in those following alcohol withdrawal; such patients can be more sensitive to the adverse effects of psychotropic drug. Recent interesting results indicate anticonvulsant and analgesic activity of tianeptine and its possible interaction with adenosine A1 receptors.
There is some interaction that occurs with both the estrogen and progesterone receptors, so it is recommended to use an aromatase inhibitor (AI), especially if you decide to stack it with test, or any other aromatizating compound. Estrogen and progesterone side effects such as gynecomastia, water retention, and high blood pressure are possible.
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Category: Other pharmaceuticals
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