Strong Analgesic Peptide Hormone Dermorphin For Pain Killer

Model: peptides powder
Place of Origin: Hubei,China (Mainland)
Brand Name: Dermorphin
CAS No.: 142689-18-7
Purity: 99%
Tasimelteon color: white
Tasimelteon appearence: Powder
Tasimelteon Alias: Hyp-6
Tasimelteon Formula: C43H57N9O9
Tasimelteon Standard: USP
Tasimelteon package: disguised package
Tasimelteon methods: T/T, Westeron Union, Money Gram, Bitcoin
Tasimelteon lead time: within 24hour after payment confirmed
Tasimelteon Delivery time: 5-7 day
Tasimelteon Usage: analgesic, pain killer

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Product Description

Payment & Shipping Terms Supply Capacity
Unit Price:1.0 USDProduction Capacity:5000kg per month
Trade Term:FOB,CIFPacking:disguised package
Payment Terms:T/T, WU, Money GramDelivery Date:within 24 hours after...
Min. Order:10 Gram
Means of Transport:Ocean, express, Air

Pharmaceutical Raw Materials Tasimelteon Hetlioz For Good Sleep


Tasimelteon Basic Info


Tasimelteon Name Tasimelteon
Other Name:Hetlioz
Tasimelteon Purity: >99%
Tasimelteon CAS: 609799-22-6
Tasimelteon Molecular Weight: 245.322
Tasimelteon Certification: ISO 9001, USP, BP
Tasimelteon State: Solid
Tasimelteon Appearance: White Crystalline Powder
Tasimelteon Mf: C15h19no2
Tasimelteon Boiling Point: 442.553°c


What is Tasimelteon?


Tasimelteon is a melatonin receptor agonist. It works by targeting receptors in the brain that control the timing of the sleep-wake cycle. In clinical trials, totally blind individuals with Non-24 who were treated with tasimelteon slept longer during the night. Tasimelteon was also found to decrease the amount of time totally blind individuals with Non-24 slept during the day.


Tasimelteon vs Ramelteon


Uses. Both drug treat sleep disorders. Tasimelteon is approved for Non-24-Hour Sleep-Wake Disorder, ramelteon is approved for insomnia (difficulty falling asleep).


Mechanism. Both bind melatonin receptors
Receptor binding. Tasimelteon has 2-5x greater affinity for the melatonin receptor MT2 than MT1. Ramelteon has 10x the affinity for the melatonin receptor MT1 than MT2.


Half-life. The half-life of tasimelteon is about 1 hour (according to one source). The half-life of ramelteon is 1-2.6 hours.


Interactions. Ramelteon has drug-drug interactions with Amiodarone, Ciprofloxacin, Fluvoxamine, Ticlopidine. Since tasimelteon is metabolized by CYP1A2 and CYP3A4/5, it interactions with many drug also metabolized by these enzymes.


Tasimelteon Dosing


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


For oral dosage form (capsules):
For non-24-hour sleep-wake disorder:
Adults—20 milligrams (mg) per day, taken before bedtime.
Children—Use and dose must be determined by your doctor.


Tasimelteon Specification


Testing ItemsSpecificationsResult
AppearanceWhite to off-white crystalline powderComplies
IdentificationHPLC: Positive
IR: Positive
Complies
Complies

Loss on drying≤0.5%0.01%
Residue on Ignition≤0.1%0.01%
Related Substances (HPLC)Impurity A≤0.1%
Impurity B≤0.1%
Impurity C≤0.1%
Any other single impurity≤0.1%
Total impurities≤0.5%
N/D
N/D
0.04%
N/D
0.04%

Chiral Purity (HPLC)≥99.9%100%
Heavy Metals≤10ppmComplies
Residual solventsEthanol≤5000ppm
Tetrahydrofuran≤720ppm
Ethyl acetate≤5000ppm
Toluene≤890ppm
300 ppm
N/D
600 ppm
31 ppm

Assay98.0 - 102.0% ( on anhydrous basis)100.2%
ConclusionComplies with the Enterprise Standard.



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Category: Peptide steroid